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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Association between mean platelet volume and kidney events in patients with type 2 diabetes mellitus

Syuhei Watanabe1, Kenichi Tanaka1,2, Hiroshi Kimura1,2

  • 1Department of Nephrology and Hypertension, Fukushima Medical University, Fukushima, Japan.

Journal of Diabetes Investigation
|November 27, 2025
PubMed
Abstract

Insights

Elevated mean platelet volume (MPV) is linked to increased kidney and cardiovascular events in type 2 diabetes patients. This finding suggests MPV could be a useful biomarker for predicting disease progression.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Mean platelet volume (MPV) is elevated in type 2 diabetes mellitus.
  • Increased MPV is associated with poor glycemic control and diabetic vascular complications.
  • Evidence linking MPV to hard kidney outcomes is limited.

Purpose of the Study:

  • To investigate the relationship between MPV and kidney events in type 2 diabetes mellitus patients.

Main Methods:

  • Retrospective analysis of 1,076 Japanese type 2 diabetes patients.
  • Categorization into quartiles based on baseline MPV.
  • Primary endpoint: kidney events (≥50% eGFR decline or end-stage kidney disease).

Main Results:

  • 97 kidney events occurred during 5.3 years median follow-up.
  • The highest MPV quartile (Q4) showed a significantly increased risk of kidney events (aHR 2.05).
  • Higher MPV levels were associated with increased cardiovascular event risk.

Conclusions:

  • Elevated MPV is independently associated with kidney and cardiovascular events in type 2 diabetes.
  • MPV may be a simple biomarker for predicting kidney disease progression in this population.
Keywords:
DiabetesKidneyMean platelet volume

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