Related Experiment Video
Updated: Jul 20, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
[Sarcomatoid renal carcinoma with malignant heterologous elements: case report]
Francisco Javier Torres Gómez1, Francisco Javier Torres Olivera
1Servicios de Anatomía Patológica del Hospital de Jerez de la Frontera, Cádiz y del Hospital Universitario Virgen Macarena, Sevilla, España. javiertorresgomez@yahoo.es
Objective:
The sarcomatoid pattern represents the histological type of renal carcinoma with the poorest prognosis, receiving the grade 4 of the Furhman classification consistently.
Methods:
We report the case of a 80-year-old male who underwent nephroureterectomy with the pathologic diagnosis of sarcomatoid renal carcinoma with areas of chondro and osteosarcoma, as well as squamous cell differentiation. It is an exceptional case because it is rare to find all these elements in the same tumor.
Results:
The study of the surgical specimen enables in most cases the identification of some of the classic histological patterns of renal carcinoma, nevertheless an immunohistochemical study is of great value for proper classification of the neoplasia and differential diagnosis with other renal lesions, mainly sarcomas.
Conclusions:
The presence of malignant heterologous elements, as in our case, will confirm the prognosis of these neoplasias, which really don't have an effective treatment.
Related Concept Videos
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...