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Related Experiment Video

Updated: Jul 20, 2026

Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

Published on: April 3, 2019

The enteric purinergic P2Y1 receptor.

Jackie D Wood¹

¹Department of Physiology and Cell Biology and Internal Medicine, College of Medicine, Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, Ohio 43210-1218, USA. wood.13@osu.edu <wood.13@osu.edu>

Current Opinion in Pharmacology

|August 29, 2006

Summary

The P2Y(1) purinergic receptor in the gut regulates intestinal secretion and motility. Targeting this receptor or its signaling pathways may offer new therapeutic strategies for gastrointestinal disorders.

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Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

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Published on: April 3, 2019

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

Area of Science:

Gastroenterology
Neuroscience
Pharmacology

Background:

The P2Y(1) purinergic receptor is newly identified in the enteric nervous system.
It is present at intestinal neuromuscular junctions, influencing gut functions.

Purpose of the Study:

To investigate the role of the P2Y(1) receptor in enteric neural control.
To explore its involvement in intestinal secretion and motility.

Main Methods:

The study focuses on the expression and function of P2Y(1) receptors in secretomotor and motor neurons.
It examines the action of synaptically released ATP on these receptors.

Main Results:

P2Y(1) receptors mediate ATP-stimulated electrolyte and water secretion.
ATP acting on P2Y(1) receptors inhibits intestinal circular muscle contraction.

Conclusions:

P2Y(1) receptors are crucial for regulating intestinal secretion and motility.
These receptors and their downstream signaling are potential therapeutic targets for gut disorders.