Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

366
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
366
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.7K
Parasympathetic Signaling01:30

Parasympathetic Signaling

2.0K
Parasympathetic signaling plays a crucial role in regulating various physiological processes. It involves the release of acetylcholine (ACh) by parasympathetic neurons, which can have localized and short-lived effects. The majority of ACh released is rapidly inactivated at the synapse by the enzyme acetylcholinesterase (AChE), which hydrolyzes Ach into choline and acetate. Additionally, the tissue cholinesterase deactivates any ACh diffusing into the surrounding tissues.
The effects of...
2.0K
Regulation of the Digestive System01:25

Regulation of the Digestive System

775
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
775
Parasympathetic Division of the ANS01:08

Parasympathetic Division of the ANS

2.2K
The parasympathetic division of the autonomic nervous system (ANS) regulates rest and digestion functions in the body. It works in opposition to the sympathetic division, promoting relaxation, conservation of energy, and digestion. The parasympathetic division consists of preganglionic fibers originating from specific cranial nerves (III, VII, IX, X) and the sacral spinal nerves (S2-S4). These fibers synapse with postganglionic neurons in the terminal ganglia, innervating various organs and...
2.2K
Intestinal Phase of Digestion01:29

Intestinal Phase of Digestion

5.3K
The intestinal phase of digestion is the third and final stage of the digestive process, occurring after the cephalic and gastric phases. It begins when chyme, a partially digested mixture of food and digestive enzymes, enters the small intestine from the stomach. This phase is crucial for nutrient absorption and involves complex hormonal and enzymatic interactions.
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple rather than specific autoantibodies were identified in irritable bowel syndrome with HuProt™ proteome microarray.

Frontiers in physiology·2022
Same author

[Unique characteristics of "the second brain" - The enteric nervous system].

Sheng li xue bao : [Acta physiologica Sinica]·2020
Same author

Serotonergic Integration In the Intestinal Mucosa.

Current pharmaceutical design·2020
Same author

Sera with anti-enteric neuronal antibodies from patients with irritable bowel syndrome promote apoptosis in myenteric neurons of guinea pigs and human SH-Sy5Y cells.

Neurogastroenterology and motility·2018
Same author

Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells.

Neuroscience bulletin·2018
Same author

Enteric Neurobiology: Discoveries and Directions.

Advances in experimental medicine and biology·2016

Related Experiment Video

Updated: Aug 15, 2025

Methods to Study Epithelial Transport Protein Function and Expression in Native Intestine and Caco-2 Cells Grown in 3D
11:27

Methods to Study Epithelial Transport Protein Function and Expression in Native Intestine and Caco-2 Cells Grown in 3D

Published on: March 16, 2017

16.5K

Serotonergic Paracrine Targets in the Intestinal Mucosa.

Jackie D Wood1

  • 1Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH, USA. Jackie.Wood@osumc.edu.

Advances in Experimental Medicine and Biology
|December 31, 2022
PubMed
Summary

Serotonin acts as a paracrine signal in the gut, influencing intestinal cell activity and plasticity. This signaling links various cell types, integrating functions for overall digestive homeostasis.

Keywords:
Enterochromaffin cellsMast cellsSerotonergic receptorsSerotoninSpinal afferents

More Related Videos

Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells
10:04

Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells

Published on: September 26, 2018

10.4K
Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.0K

Related Experiment Videos

Last Updated: Aug 15, 2025

Methods to Study Epithelial Transport Protein Function and Expression in Native Intestine and Caco-2 Cells Grown in 3D
11:27

Methods to Study Epithelial Transport Protein Function and Expression in Native Intestine and Caco-2 Cells Grown in 3D

Published on: March 16, 2017

16.5K
Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells
10:04

Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells

Published on: September 26, 2018

10.4K
Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.0K

Area of Science:

  • Gastroenterology
  • Neuroscience
  • Cell Biology

Background:

  • Serotonin is a key neurotransmitter in the enteric nervous system.
  • Beyond neurotransmission, serotonin functions as a paracrine mediator in the digestive tract.
  • It plays a crucial role in the integrated physiology of intestinal mucosal cells.

Purpose of the Study:

  • To elucidate the paracrine signaling role of serotonin in the intestinal mucosa.
  • To understand how paracrine serotonin influences cellular plasticity and inter-cell communication.
  • To identify the specific cell types involved in serotonergic paracrine signaling in the small intestine.

Main Methods:

  • The study focuses on the functional roles and interactions of specific cell populations within the intestinal mucosa.
  • Analysis involves understanding paracrine signaling mechanisms and their impact on cellular phenotypes.
  • The research integrates knowledge of cell biology and neurogastroenterology to map signaling pathways.

Main Results:

  • Serotonin acts as a major paracrine signaling molecule in the intestinal mucosa.
  • Paracrine serotonin can initiate or suppress activity in diverse phenotypic cell classes.
  • This signaling underlies phenotypic plasticity and links different cell types, forming higher-order physiological organization.

Conclusions:

  • Serotonergic paracrine signaling is vital for integrating diverse cellular functions in the small intestine.
  • It contributes to phenotypic plasticity within and between cell classes.
  • This mechanism links enterochromaffin cells, enteric mast cells, spinal afferents, sympathetic neurons, and enteric neurons for coordinated function.