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[Arterial chemoembolization using microencapsulated anticancer drugs].

K Sato1, T Kato

  • 1Dept. of Urology, Akita University School of Medicine.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|June 1, 1990
PubMed
Summary

Chemoembolization using microcapsules effectively treats various cancers by causing tumor infarction and sustained drug delivery. This innovative treatment offers significant tumor reduction and improved survival with minimal systemic toxicity.

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[A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) in dogs.

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Area of Science:

  • Interventional Radiology
  • Oncology
  • Materials Science

Context:

  • Malignant tumors present significant therapeutic challenges.
  • Selective intra-arterial drug delivery offers targeted treatment options.
  • Ethylcellulose microcapsules provide a novel vehicle for anticancer agents.

Purpose:

  • To evaluate the efficacy and safety of chemoembolization using ethylcellulose microcapsules for various malignant tumors.
  • To assess tumor reduction, impact on surgical outcomes, and patient survival.
  • To determine the feasibility of microcapsule chemoembolization as a preoperative or palliative measure.

Summary:

  • Seven hundred fifty-nine patients with liver, kidney, bladder, prostate, lung, and other cancers underwent chemoembolization.

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  • Significant tumor reduction (≥50%) was observed in 18% of hepatoma, 19% of renal cell carcinoma, and 54% of bladder and prostate carcinomas.
  • The procedure facilitated radical surgery and improved survival in locally invasive renal cell and bladder carcinomas, with mild systemic toxicity.

    • Impact:

    • Microcapsule chemoembolization is a viable treatment for diverse tumors, demonstrating low morbidity and mortality.
    • This technique can be integrated into multidisciplinary cancer therapy.
    • The study highlights the potential of targeted drug delivery via microcapsules for improved oncological outcomes.