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Potential future targets for treating ocular neovascularization

Fina C Barouch1, Joan W Miller

  • 1Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA.

Ophthalmology Clinics of North America
|August 29, 2006
PubMed

Insights

Mediators drive ocular neovascularization (NV). Targeting these mediators, alongside inflammation and apoptosis, offers potential treatments for ocular NV, possibly through combined therapeutic approaches.

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Pharmacology

Background:

  • Ocular neovascularization (NV) is a significant cause of vision loss.
  • Multiple signaling pathways and cellular processes contribute to ocular NV development.

Purpose of the Study:

  • To review potential therapeutic targets for ocular NV.
  • To explore the role of angiogenesis, inflammation, and apoptosis in ocular NV.
  • To discuss the potential of combination therapies for ocular NV.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of mediators involved in ocular NV.
  • Evaluation of therapeutic strategies targeting angiogenesis, inflammation, and apoptosis.

Main Results:

  • Numerous mediators identified as potential targets for ocular NV treatment.
  • Several targets have shown promise in preclinical models and are under clinical investigation.
  • Non-angiogenic pathways like inflammation and apoptosis are also relevant therapeutic avenues.

Conclusions:

  • Targeting various mediators, including those involved in angiogenesis, inflammation, and apoptosis, is crucial for effective ocular NV treatment.
  • Combined therapeutic strategies may offer synergistic benefits for managing ocular NV.

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