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Updated: Jul 20, 2026
10:22
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
Allergic reactions due to mizolastine
Antonia Vythoulka1, Constantinos Pitsios, Evangelia Kompoti
1Allergy and Clinical Immunology Outpatient Department, Social Insurance Institute, Thessaloniki, Greece.
Summary
Antihistamine allergy is rare but possible. Skin tests confirmed two patients had anaphylaxis caused by mizolastine, an H1 blocker, highlighting the need for accurate allergy diagnosis.
Area of Science:
- Immunology
- Pharmacology
Background:
- IgE-mediated allergic reactions to antihistamines are uncommon.
- Mizolastine is a commonly prescribed H1 blocker.
Observation:
- Two patients presented with anaphylaxis.
- One case required differentiating from food allergy.
- Diagnosis was confirmed via skin testing.
Findings:
- Skin tests were positive for mizolastine.
- Tests for inert ingredients and other H1/H2 blockers were negative.
- In vivo testing demonstrated high sensitivity for antihistamine allergy.
Implications:
- Confirms the possibility of rare antihistamine-induced allergies.
- Highlights the utility of skin testing in diagnosing drug allergies.
- Underscores the importance of considering drug-induced anaphylaxis in differential diagnoses.
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