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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Published on: May 14, 2013

[Stent thrombosis in the modern era: incidence, outcome and predictive factors]

José R Balaguer-Malfagón1, Francisco Pomar-Domingo, Juan V Vilar-Herrero

  • 1Servicio de Cardiología, Consorcio Hospital General Universitario de Valencia, Valencia, España. joseramon@comv.es

Revista Espanola De Cardiologia
|August 30, 2006
PubMed

Insights

Stent thrombosis, a serious complication after percutaneous coronary intervention, occurred in 2.23% of patients. Key predictors include acute myocardial infarction and stopping clopidogrel early.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Biomedical Engineering

Context:

  • Percutaneous coronary intervention (PCI) is a common procedure for treating coronary artery disease.
  • Coronary stent thrombosis (ST) is a rare but devastating complication following PCI.
  • The incidence of ST varies, particularly in high-risk scenarios and with different stent types.

Purpose:

  • To investigate the incidence, outcomes, and predictors of coronary stent thrombosis.
  • To analyze ST occurrence in a patient cohort receiving both conventional and drug-eluting stents.
  • To identify factors associated with ST to improve patient management.

Summary:

  • This study analyzed 404 patients undergoing PCI, finding an overall ST incidence of 2.23%.
  • Mortality associated with ST was 22.2%, with 66.6% experiencing non-fatal myocardial infarction.
  • Significant predictors of ST included acute myocardial infarction, multiple stent placement, poor ejection fraction, small stent diameter, residual dissection, and premature clopidogrel discontinuation.

Impact:

  • Findings highlight the significant morbidity and mortality associated with ST.
  • Identifies critical risk factors, enabling targeted prevention strategies.
  • Emphasizes the importance of adherence to antiplatelet therapy, such as clopidogrel, post-PCI.

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