Related Experiment Video
Updated: Jul 20, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Amisulpride-induced hyperprolactinemia is reversible following discontinuation
Thomas Paparrigopoulos1, John Liappas, Elias Tzavellas
1Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Vas. Sofias Ave. 115 28 Athens, Greece. Thomas.Paparrigopoulos@iop.kcl.ac.uk
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|August 30, 2006
Summary
Amisulpride significantly elevates prolactin levels in patients, a side effect that rapidly reverses upon drug discontinuation. This prolactin increase is independent of amisulpride dosage or treatment duration.
Area of Science:
- Pharmacology
- Endocrinology
- Psychiatry
Background:
- Amisulpride is an atypical antipsychotic known to raise prolactin levels.
- Limited studies have quantified the extent of amisulpride's prolactin-elevating effects.
- Investigating the impact of amisulpride on prolactin and its reversibility is crucial.
Purpose of the Study:
- To determine the effect of amisulpride on plasma prolactin levels.
- To assess the reversibility of amisulpride-induced hyperprolactinemia.
Main Methods:
- 17 patients received amisulpride (50-800 mg/day) or combination therapy.
- Plasma prolactin levels were measured during treatment and after drug withdrawal.
- Data analyzed for correlation with dosage and duration.
Main Results:
- All patients on amisulpride exhibited hyperprolactinemia (mean 62.5±33.0 ng/ml).
- Females showed higher prolactin levels than males.
- Hyperprolactinemia significantly reduced (mean 12.3±6.7 ng/ml) after amisulpride discontinuation (p<0.000).
Conclusions:
- Amisulpride causes a pronounced prolactin-elevating effect.
- This effect is independent of amisulpride dosage and duration.
- Hyperprolactinemia rapidly reverses upon amisulpride withdrawal.
Related Concept Videos
01:21Drugs for Treatment of Constipation-Predominant IBS
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
01:24Mania and Antimanic Drugs: Overview
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
01:24Parkinson's Disease: Treatment
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
01:23Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
01:23Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
01:28Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...