Related Experiment Video
Updated: Jul 20, 2026

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS
Published on: November 8, 2024
Comparative bioequivalence study between a novel matrix transdermal delivery system of fentanyl and a commercially
Jean-Francois Marier1, Mary Lor, Josée Morin
1MDS Pharma Services, Montreal (St-Laurent), Quebec, Canada.
Aim:
To determine the pharmacokinetics, safety and performance of a novel matrix formulation of fentanyl.
Methods:
Transdermal fentanyl was administered as the novel matrix and the Durogesic reservoir formulations (24 subjects, 100 microg h(-1)) in a randomized, fully replicate, four-way crossover study. Serum concentrations of fentanyl were assayed by LC/MS/MS. Pharmacokinetic parameters of fentanyl and performance (adherence and skin irritability) were evaluated.
Results:
Test/reference ratio (90% confidence intervals) for AUC(0-t), AUC(inf) and C(max) were 105.5% (99.4, 112.0), 105.3% (99.3, 111.6) and 111.4% (100.4, 123.6), respectively. Adherence and skin irritability results of the two formulations were similar.
Conclusion:
The two formulations are expected to result in similar efficacy for the management of severe pain.
Related Concept Videos
Transdermal Drug Delivery Systems
Oral Drug Delivery Systems: Continuous-Release Systems
Modified-Release Drug Delivery Systems: Rate-Programmed II
Bioequivalence studies: Biowaivers
Modified-Release Drug Delivery Systems: Bioavailability
Bioequivalence: Overview