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The plasma levels of soluble P-selectin in subjects with prediabetes

T Dogru1, I Tasci, A Sonmez

  • 1Department of Internal Medicine, Gulhance School of Medicine, Etlik, Ankara, Turkey. teomandogru@yahoo.com

International Journal of Clinical Practice
|August 31, 2006
PubMed

Insights

Soluble P-selectin (sP-selectin) did not significantly differ in prediabetes, suggesting it may not drive the increased cardiovascular risk associated with this condition. Prediabetes is linked to higher insulin resistance and lower HDL cholesterol.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Hematology

Background:

  • Prediabetes is a significant risk factor for cardiovascular disease (CVD) and mortality.
  • Soluble P-selectin (sP-selectin), a marker of platelet activation, is implicated in vascular events.
  • The role of sP-selectin in prediabetes-associated vascular complications requires further investigation, particularly in the absence of confounding factors.

Purpose of the Study:

  • To investigate sP-selectin levels in prediabetic individuals without hypertension, obesity, or dyslipidemia.
  • To compare sP-selectin, high-sensitivity C-reactive protein (hsCRP), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) between prediabetic subjects and healthy controls.

Main Methods:

  • A case-control study involving 40 prediabetic subjects (24 with impaired fasting glucose, 16 with impaired glucose tolerance) and 40 age-, sex-, and BMI-matched healthy controls.
  • Measurements included sP-selectin, hsCRP, and HOMA-IR.
  • Statistical analysis was performed to compare groups, with a study power of 0.93 for sP-selectin.

Main Results:

  • No significant difference in sP-selectin levels was observed between prediabetic subjects and controls (p = 0.12).
  • Prediabetic subjects exhibited similar hsCRP levels (p = 0.29) but significantly higher HOMA-IR indexes (p < 0.001) and lower HDL cholesterol (p = 0.001) compared to controls.
  • The study possessed high statistical power to detect differences in sP-selectin.

Conclusions:

  • sP-selectin does not appear to contribute to the prothrombotic state or accelerated atherogenesis in prediabetes.
  • The findings highlight the importance of insulin resistance and dyslipidemia in the cardiovascular risk profile of prediabetes.
  • Further research may explore other inflammatory markers and platelet activation pathways in prediabetes.

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