Related Experiment Video

Updated: Jul 20, 2026

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

[Effect of Pentavac and MMR vaccination on the intestine.]

Bjarni Thornjóðleifsson1, Katrín Davíðsdóttir, Ulfur Agnarsson

  • 1Landspitali University Hospital, Hringbraut, 101 Reykjavík, Iceland. bjarnit@landspitali.is.

Laeknabladid
|August 31, 2006
PubMed

Insights

The measles, mumps, and rubella (MMR) vaccine did not cause intestinal inflammation in infants. This finding challenges the enterocolitis theory linking MMR vaccination to autism.

Area of Science:

  • Pediatric immunology
  • Gastroenterology
  • Vaccine safety research

Context:

  • Concerns persist regarding the safety of infant vaccinations, specifically the measles, mumps, and rubella (MMR) vaccine.
  • A hypothesis suggests a link between MMR vaccination, autism, and a condition called "enterocolitis" characterized by intestinal inflammation.

Purpose:

  • To investigate if MMR vaccination is associated with sub-clinical intestinal inflammation.
  • To evaluate the proposed gut-brain interaction central to the autistic "enterocolitis" hypothesis.

Summary:

  • This study measured fecal calprotectin levels in 109 infants before and after receiving Pentavac and MMR vaccines.
  • No significant increase in fecal calprotectin was observed following either vaccination, indicating no induced intestinal inflammation.

Impact:

  • Provides evidence against the gut-brain interaction theory linking MMR vaccination to autism via enterocolitis.
  • Supports the safety profile of the MMR vaccine concerning gastrointestinal inflammatory responses.
Abstract

More Related Videos

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment08:33

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.