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Related Experiment Videos

Learning, aging and intrinsic neuronal plasticity.

John F Disterhoft1, M Matthew Oh

  • 1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA. jdisterhoft@northwestern.edu

Trends in Neurosciences
|September 1, 2006
PubMed
Summary
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Learning and aging alter brain cell excitability. Reduced afterhyperpolarization (AHP) and accommodation aid learning, while increased AHP and accommodation in aging may impair it.

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Cognitive Aging

Background:

  • Intrinsic neuronal excitability, including post-burst afterhyperpolarization (AHP) and spike-frequency accommodation, changes during learning and aging.
  • These cellular changes in the brain may underlie cognitive function and decline.

Purpose of the Study:

  • To review in vitro and in vivo studies on neuronal excitability changes during learning and aging.
  • To explore the relationship between AHP, synaptic plasticity, and learning.
  • To investigate the role of AHP in age-related learning impairments.

Main Methods:

  • Review of in vitro electrophysiological experiments on brain slices.
  • Analysis of in vivo single-neuron recording studies.
  • Comparison of neuronal properties in young, learning, and aging subjects.

Related Experiment Videos

Main Results:

  • Pyramidal neurons show reduced AHP and accommodation after learning a task.
  • Aging pyramidal neurons exhibit enhanced AHP and accommodation.
  • In vivo data complement in vitro findings regarding neuronal excitability.

Conclusions:

  • Intrinsic AHP levels may dictate the extent of synaptic plasticity and learning capacity.
  • A reduction in AHP is necessary prior to learning for both young and aging individuals.
  • Enhanced AHP in aging may contribute to cognitive deficits and learning impairments.