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Trace element status (Se, Zn, Cu) in heart failure

Feridun Koşar1, Ibrahim Sahin, Cağatay Taşkapan

  • 1Department of Cardiology, Medical Faculty, Inönü University, Malatya, Turkey. mferidunkosar@yahoo.com

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|September 1, 2006
PubMed

Insights

Heart failure patients show altered trace element levels, with lower selenium and zinc, and higher copper. These changes were consistent between idiopathic dilated and ischemic cardiomyopathy.

Area of Science:

  • Cardiology
  • Trace Element Metabolism
  • Biochemistry

Background:

  • Trace elements are implicated in heart failure pathogenesis.
  • Understanding serum trace element profiles in heart failure is crucial.

Purpose of the Study:

  • To assess serum selenium (Se), zinc (Zn), and copper (Cu) in heart failure (HF) patients.
  • To compare trace element levels in idiopathic dilated cardiomyopathy (IDCM) and ischemic cardiomyopathy (ICM) versus healthy controls.

Main Methods:

  • Serum Se, Zn, and Cu levels were measured in 54 HF patients and 30 healthy controls.
  • Atomic absorption spectrophotometry was used for trace element analysis.
  • HF patients were categorized into IDCM and ICM subgroups.

Main Results:

  • HF patients exhibited significantly lower serum Se and Zn compared to controls (p=0.000, p<0.01).
  • HF patients showed significantly higher serum Cu concentrations than controls (p=0.000).
  • No significant differences in trace element status were found between IDCM and ICM patients.

Conclusions:

  • Heart failure is associated with distinct alterations in serum Se, Zn, and Cu concentrations.
  • Serum trace element profiles for Se, Zn, and Cu are similar in IDCM and ICM.
  • No significant correlations were observed between trace element levels and echocardiographic/hemodynamic parameters.
Abstract

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