Trace element status (Se, Zn, Cu) in heart failure
Feridun Koşar1, Ibrahim Sahin, Cağatay Taşkapan
1Department of Cardiology, Medical Faculty, Inönü University, Malatya, Turkey. mferidunkosar@yahoo.com
Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|September 1, 2006
Summary
Heart failure patients show altered trace element levels, with lower selenium and zinc, and higher copper. These changes were consistent between idiopathic dilated and ischemic cardiomyopathy.
Area of Science:
- Cardiology
- Trace Element Metabolism
- Biochemistry
Background:
- Trace elements are implicated in heart failure pathogenesis.
- Understanding serum trace element profiles in heart failure is crucial.
Purpose of the Study:
- To assess serum selenium (Se), zinc (Zn), and copper (Cu) in heart failure (HF) patients.
- To compare trace element levels in idiopathic dilated cardiomyopathy (IDCM) and ischemic cardiomyopathy (ICM) versus healthy controls.
Main Methods:
- Serum Se, Zn, and Cu levels were measured in 54 HF patients and 30 healthy controls.
- Atomic absorption spectrophotometry was used for trace element analysis.
- HF patients were categorized into IDCM and ICM subgroups.
Main Results:
- HF patients exhibited significantly lower serum Se and Zn compared to controls (p=0.000, p<0.01).
- HF patients showed significantly higher serum Cu concentrations than controls (p=0.000).
- No significant differences in trace element status were found between IDCM and ICM patients.
Conclusions:
- Heart failure is associated with distinct alterations in serum Se, Zn, and Cu concentrations.
- Serum trace element profiles for Se, Zn, and Cu are similar in IDCM and ICM.
- No significant correlations were observed between trace element levels and echocardiographic/hemodynamic parameters.
Related Concept Videos
01:30Heart Failure IV: Classification and Diagnostic Evaluation
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
01:26Heart Failure III: Clinical Manifestations
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
01:29Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
01:30Dysrhythmias V: Evaluating Dysrhythmias
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
01:22Heart Failure VI: Adjunct Therapies
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
01:30Heart Failure V: Medical Management
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...