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Related Concept Videos

Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Frictional Force01:07

Frictional Force

When a body is in motion, it encounters resistance because the body interacts with its surroundings. This resistance is known as friction, a common yet complex force whose behavior is still not completely understood. Friction opposes relative motion between systems in contact, but also allows us to move. Friction arises in part due to the roughness of surfaces in contact. For one object to move along a surface, it must rise to where the peaks of the surface can skip along the bottom of the...
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Anchoring Junctions01:03

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...

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Related Experiment Video

Updated: Jul 20, 2026

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
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Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Frictional adhesion: A new angle on gecko attachment.

K Autumn1, A Dittmore, D Santos

  • 1Department of Biology, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR 97219, USA. autumn@lclark.edu

The Journal of Experimental Biology
|September 1, 2006
PubMed
Summary

Gecko adhesion increases with shear force, not peeling like tape. Their unique dry adhesive mechanism relies on a critical angle for detachment, explaining their climbing ability.

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Last Updated: Jul 20, 2026

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
12:26

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay
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Published on: September 27, 2021

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Area of Science:

  • Biomechanics
  • Adhesion Science
  • Zoology

Background:

  • Geckos utilize dry adhesive pads on their toes for climbing.
  • Detachment mechanisms include microscale seta angle changes and macroscale toe peeling.
  • Gecko adhesion while inverted remains unexplained.

Purpose of the Study:

  • Investigate gecko adhesion mechanisms, specifically the role of shear force.
  • Test hypotheses regarding critical angle detachment versus tape-like peeling.
  • Develop a new model for gecko pad attachment.

Main Methods:

  • Tested adhesion in isolated setal arrays and live gecko toes.
  • Measured adhesion dependence on shear force and detachment angle.
  • Compared experimental results with existing adhesive models.

Main Results:

  • Adhesion was found to be directly dependent on shear force.
  • Detachment angle was independent of applied force.
  • The hypothesis of tape-like peeling was rejected.

Conclusions:

  • Gecko adhesion is governed by a critical angle of release, not macroscale peeling.
  • A new 'frictional adhesion' model explains gecko attachment and low detachment forces.
  • This model clarifies how geckos maintain adhesion, even when inverted.