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Updated: Jul 20, 2026
In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
In vitro anti-HIV activity of a Chinese fungus extract
Zi-Chun Xiang1, Yan Jiang, Shun-Xing Guo
1Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing.
Objective:
To investigate the inhibitory effect of the mycelium extract from a Chinese fungus (M1) on HIV-1 and its mode of action.
Methods:
Several in vitro methods including time of action, time of addition and PCR were used to test the mode of action of M1.
Results:
M1 inhibited acute HIV infection in vitro and was effective when it was added 12 h after infection. PCR analysis of infected cells demonstrated that M1 delayed the appearance of late product of reverse transcription and HIV was blocked before its RNA expression.
Conclusion:
The target of M1 is post-integration of proviral DNA.
