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Endothelial monocyte-activating polypeptide-II and its functions in (patho)physiological processes

Remco van Horssen1, Alexander M M Eggermont, Timo L M ten Hagen

  • 1Laboratory of Experimental Surgical Oncology, Department of Surgical Oncology, Erasmus University MC - Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. r.vanhorssen@ncmls.ru.nl

Cytokine & Growth Factor Reviews
|September 2, 2006
PubMed

Insights

Endothelial monocyte-activating polypeptide-II (EMAP-II) is a cytokine involved in inflammation and angiogenesis. This review covers EMAP-II

Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Biology

Background:

  • Endothelial monocyte-activating polypeptide-II (EMAP-II) is a pro-inflammatory cytokine.
  • Its precursor, proEMAP/p43, is linked to protein translation via the tRNA multisynthetase complex.
  • Both proEMAP/p43 and EMAP-II exhibit cytokine properties and affect various cell types.

Purpose of the Study:

  • To review existing data on the isolation, expression, and functions of EMAP-II.
  • To explore EMAP-II's roles in physiological and pathological conditions, particularly cancer.
  • To discuss proEMAP/p43 processing into EMAP-II and potential therapeutic applications.

Main Methods:

  • Literature review of published data.
  • Analysis of studies on EMAP-II isolation and expression.
  • Examination of research on EMAP-II functions in various cell types and disease models.

Main Results:

  • EMAP-II possesses pro-inflammatory and anti-angiogenic activities.
  • ProEMAP/p43, the precursor, also has cytokine properties and is involved in translation.
  • EMAP-II and its precursor impact endothelial cells, immune cells, and fibroblasts.

Conclusions:

  • EMAP-II is a multifunctional cytokine with significant roles in both normal physiology and disease, especially cancer.
  • Understanding the processing of proEMAP/p43 to EMAP-II is crucial.
  • EMAP-II holds potential for novel cancer therapies.

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