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How T lymphocytes recognize lipid antigens

Gennaro De Libero1, Lucia Mori

  • 1Experimental Immunology, Department of Research, University Hospital, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. gennaro.delibero@unibas.ch

FEBS Letters
|September 5, 2006
PubMed

Recognition of lipid antigens by T lymphocytes is well established. Lipids are recognized by T cells when presented in association with CD1 antigen-presenting molecules. Both microbial and self lipids stimulate specific T lymphocytes, thus participating in immune reactions during infections and autoimmune diseases. The immune system uses a variety of strategies to solubilise lipid antigens, to facilitate their internalization, processing, and loading on CD1 molecules. Recent studies in the field of lipid antigen presentation have revealed new mechanisms which allow the immune system to sense lipids as stimulatory antigens.

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