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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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Accessory Structures of the Skin: Sebaceous Glands

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Related Experiment Video

Updated: Jul 20, 2026

A Rat Model of Compound Acne
03:10

A Rat Model of Compound Acne

Published on: November 1, 2024

Expert committee recommendations for acne management.

Andrea L Zaenglein1, Diane M Thiboutot

  • 1Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. azaenglein@psu.edu

Pediatrics
|September 5, 2006
PubMed
Summary

Topical retinoids are foundational for acne treatment, targeting multiple causes. Combining them with antimicrobials offers faster, superior results compared to single treatments for effective acne management.

Related Experiment Videos

Last Updated: Jul 20, 2026

A Rat Model of Compound Acne
03:10

A Rat Model of Compound Acne

Published on: November 1, 2024

Area of Science:

  • Dermatology
  • Acne Pathophysiology
  • Treatment Guidelines

Background:

  • International consensus guidelines for acne treatment were established in 2003.
  • These guidelines integrated evidence-based data with expert clinical experience.
  • Understanding of acne pathophysiology significantly influenced treatment strategies.

Purpose of the Study:

  • To outline updated, evidence-based recommendations for acne management.
  • To emphasize combination therapy for targeting multiple acne pathogenic factors.
  • To establish topical retinoids as a cornerstone of acne treatment.

Main Methods:

  • Development of consensus guidelines by an international committee of acne experts.
  • Evaluation of available scientific data and extensive clinical experience.
  • Focus on targeting key pathogenic factors in acne treatment.

Main Results:

  • Topical retinoids are recommended as the foundation of acne treatment due to their action on microcomedones and anti-inflammatory effects.
  • Combination therapy, particularly topical retinoids with antimicrobials, demonstrated superior and faster acne lesion clearance.
  • Oral antibiotics are reserved for moderate-to-severe acne, used adjunctively, and discontinued promptly.

Conclusions:

  • Acne treatment should combine therapies to address multiple pathogenic factors.
  • Topical retinoids are crucial for both initial treatment and maintenance therapy.
  • Strategic use of oral antibiotics and combination therapies optimizes acne outcomes.