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[Molecular mechanism of tissue-specific actions of SERM]
1The Institute of Molecular and Cellular Biosciences, The University of Tokyo/ERATO, JST.
Abstract:
Selective estrogen receptor modulator (SERM) is designated as synthetic ligands for estrogen receptors (ERs), exhibiting tissue-specific agonisitic/antagonisitic activities. Among SERM, raloxifen is a most clinically successful as an anti-oseteoporotic agent. Such tissue-specific actions of SERM are presumed to mediate through unusual structure alteration of liganded ERs coupled with co-regulator recruitments.
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