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Updated: Jul 20, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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Protection from autoimmunity: immunological indifference versus T-cell mediated suppression?

Lucienne Chatenoud1

  • 1Université René Descartes Paris 5, INSERM U580, Hôpital Necker-Enfants Malades, Paris, France. chatenoud@necker.fr

European Journal of Immunology
|September 5, 2006
PubMed
Summary

Immune tolerance relies on more than just cell deletion. Peripheral immune mechanisms, including CTLA-4 signaling, regulate autoreactive T cells to prevent autoimmunity.

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