Related Experiment Video
Updated: Jul 20, 2026
07:40
A 3D Spheroid Model for Glioblastoma
Published on: April 9, 2020
[Solitary giant cell collagenoma]
A Hernández-Martín1, A Torrelo, I Colmenero
1Servicio de Dermatología, Hospital del Niño Jesús, Madrid, España. atorrelo@aedv.es
Actas Dermo-Sifiliograficas
|September 8, 2006
Summary
Collagenoma, a benign skin growth, involves excess collagen tissue. This report details a rare case of a solitary giant cerebriform collagenoma in a child.
Area of Science:
- Dermatology
- Histopathology
- Genetics
Background:
- Collagenoma (collagen nevus) is a hamartomatous malformation of dermal connective tissue.
- Characterized by abnormal proliferation of normal collagen.
- Can be congenital or acquired, solitary or multiple, hereditary or sporadic.
Observation:
- Solitary collagenomas are typically sporadic and not linked to other diseases.
- They can manifest anywhere on the body.
- Histology reveals increased dermal collagen fibers and potentially decreased elastic fibers.
Findings:
- The study presents a case of a solitary giant cerebriform collagenoma.
- The lesion was located on the lumbar region of a child's back.
- Histopathological examination confirmed increased collagen and decreased elastic fibers.
Implications:
- Highlights the diverse clinical presentations of collagenomas.
- Emphasizes the importance of histological examination for diagnosis.
- Contributes to understanding rare pediatric dermatological conditions.
Related Concept Videos
01:05Type IV Collagen of Basal Lamina
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
A type IV collagen molecule has six alpha chains which can exist in...
01:11Fibril-associated Collagen
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
01:13Collagens are the Major Structural Proteins of ECM
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
01:26Extracellular Matrix
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
01:23Glycosaminoglycans
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
01:21Matrix Proteoglycans and Glycoproteins
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...