Intracellular localization of pp60c-src in human platelets
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J E Ferrell1, J A Noble, G S Martin
1Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720.
Oncogene
|July 11, 1990
Abstract:
We have studied the intracellular distribution of the proto-oncogene product pp60c-src in human platelets by immunofluorescence microscopy and by immunogold electron microscopy on frozen thin sections. Virtually all of the immunoreactive pp60c-src was found to be associated with the plasma membrane and with membranes of the surface-connected canalicular system. This localization suggests that pp60c-src may relay signals from an as yet unidentified cell surface protein to intracellular targets.