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miRBase: the microRNA sequence database.

Sam Griffiths-Jones1

  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

Methods in Molecular Biology (Clifton, N.J.)
|September 8, 2006
PubMed
Summary
This summary is machine-generated.

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The miRBase Sequence database is a key resource for microRNA (miRNA) data, offering a web interface for searching, analyzing genomic information, and linking to publications. It also provides a gene-naming service for novel miRNA discoveries.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) are crucial regulators of gene expression.
  • A centralized, accessible repository for miRNA data is essential for research.
  • miRBase serves as the primary public archive for miRNA sequences and annotations.

Purpose of the Study:

  • To describe the functions and accessibility of the miRBase Sequence database.
  • To highlight the utility of miRBase for researchers studying microRNAs.
  • To provide information on accessing and utilizing miRBase resources.

Main Methods:

  • The miRBase Sequence database provides a web interface for data retrieval.
  • Users can search for miRNA data using keywords or sequences.

Related Experiment Videos

  • The database facilitates analysis of genomic coordinates and relationships between miRNA sequences.

    • Main Results:

    • miRBase offers a user-friendly platform for accessing comprehensive miRNA data.
    • It enables researchers to link miRNA discoveries to primary literature.
    • A confidential gene-naming service is available for novel miRNA genes.

    Conclusions:

    • miRBase is a vital, freely accessible resource for the scientific community.
    • The database supports miRNA research through data sharing and analysis tools.
    • miRBase plays a critical role in standardizing miRNA nomenclature.