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Pulse wave velocity is increased in patients with transient myocardial ischemia

Johannes Baulmann1, Rami Homsi, Sakir Uen

  • 1Medizinische Poliklinik, University of Bonn, Germany bInstitute for Medical Statistics, University of Bonn, Germany. johannes.baulmann@ukb.uni-bonn.de

Journal of Hypertension
|September 8, 2006
PubMed

Insights

Arterial stiffness, measured by pulse wave velocity (PWV), is elevated in hypertensive patients with transient myocardial ischemia. This suggests PWV is a key indicator of cardiovascular risk in older adults.

Area of Science:

  • Cardiology
  • Vascular Physiology
  • Hypertension Research

Background:

  • Transient myocardial ischemia is linked to elevated pulse pressure.
  • Increased arterial stiffness may contribute to pulse pressure elevation.
  • Arterial stiffness and wave reflection are indicators of cardiovascular risk.

Purpose of the Study:

  • To determine if arterial stiffness is altered in hypertensive patients with transient myocardial ischemia.
  • To compare arterial stiffness (PWV) and wave reflection (AIx) as indicators of transient myocardial ischemia.
  • To assess the role of these parameters in high cardiovascular risk patients.

Main Methods:

  • Carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx) were measured in 74 hypertensive patients.
  • Transient myocardial ischemia was identified using 24-hour ambulatory blood pressure monitoring with ST-segment analysis.
  • Statistical analysis compared PWV and AIx between patients with and without ischemia.

Main Results:

  • Thirty of 74 patients exhibited ST-segment depressions indicative of ischemia.
  • Patients with transient myocardial ischemia showed significantly higher PWV (10.6 vs. 9.5 m/s, P=0.036).
  • No significant difference in AIx was observed; PWV correlated with pulse pressure, but AIx did not.

Conclusions:

  • Elevated PWV is associated with transient myocardial ischemia in hypertensive individuals over 60.
  • PWV appears to be a more significant indicator of silent ischemia than AIx in this population.
  • The clinical relevance of arterial stiffness and wave reflection parameters may vary with age.
Abstract

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