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Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Related Experiment Video

Updated: Jul 20, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Pediatric sclerosing rhabdomyosarcoma.

Eduardo Zambrano¹, Antonio R Pérez-Atayde, William Ahrens

¹Department of Pathology, Yale-New Haven Hospital, Yale School of Medicine, New Haven, Connecticut 06520, USA. eduardo.zambrano@yale.edu

International Journal of Surgical Pathology

|September 9, 2006

Summary

Sclerosing rhabdomyosarcoma can be misdiagnosed in children due to its appearance. Correct diagnosis requires awareness of its features and immunophenotypical evaluation for better patient outcomes.

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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

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Published on: September 13, 2019

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Last Updated: Jul 20, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Area of Science:

Oncology
Pathology
Pediatric Medicine

Background:

Sclerosing rhabdomyosarcoma is a rare variant initially described in adults.
It presents diagnostic challenges in pediatric sarcoma evaluations.

Observation:

This variant features a dense hyalinized collagenous matrix.
It can exhibit a pseudovascular growth pattern, mimicking other sarcomas.

Findings:

The study details pathologic features of sclerosing rhabdomyosarcoma in 3 pediatric cases.
Immunophenotypical evaluation is crucial for accurate diagnosis.
Cytogenetic findings suggest a potential link to embryonal rhabdomyosarcoma.

Implications:

Increased awareness of this variant is essential for correct pediatric sarcoma diagnosis.
Further genotyping may clarify its nosology, pathogenesis, and prognosis.
Accurate diagnosis impacts patient management and therapeutic strategies.