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Peripheral arterial disease. A marker of morbidity and mortality

Daniel G Federman1, Jeffrey D Kravetz, Dawn M Bravata

  • 1Yale University School of Medicine, New Haven, Connecticut, USA. daniel.federman@va.gov

Postgraduate Medicine
|September 12, 2006
PubMed

Insights

Peripheral arterial disease (PAD) affects leg arteries due to atherosclerosis. Early detection and treatment are vital for preventing serious cardiovascular events and death.

Area of Science:

  • Vascular Medicine
  • Cardiovascular Disease
  • Atherosclerosis Research

Background:

  • Peripheral arterial disease (PAD) is a widespread manifestation of systemic atherosclerosis.
  • PAD significantly increases the risk of major adverse cardiovascular events, including stroke, myocardial infarction, and mortality.
  • Many cases of PAD remain asymptomatic, leading to underdiagnosis and undertreatment.

Purpose of the Study:

  • To enhance awareness of symptomatic and asymptomatic peripheral arterial disease.
  • To highlight the importance of screening at-risk populations for PAD.
  • To provide a comprehensive overview of PAD diagnosis and management.

Main Methods:

  • Review of current medical literature on peripheral arterial disease.
  • Analysis of diagnostic criteria and testing modalities for PAD.
  • Evaluation of established and emerging therapeutic strategies for PAD.

Main Results:

  • PAD is a critical indicator of generalized atherosclerotic disease.
  • Screening identifies patients at high risk for life-threatening cardiovascular and cerebrovascular events.
  • A multi-faceted approach involving symptom recognition, diagnostic testing, and timely therapy is essential.

Conclusions:

  • Increased clinical vigilance for PAD is crucial for early identification.
  • Prompt diagnosis and intervention in PAD can mitigate significant morbidity and mortality.
  • Addressing PAD is key to managing the broader spectrum of atherosclerotic disease.

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