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Diazepam administration prevents testosterone decrease and lipofuscin accumulation in testis of mouse exposed to

R Ruffoli1, A Carpi, M A Giambelluca

  • 1Dipartimento di Morfologia Umana e Biologia Applicata, Medicina del lavoro, Università di Pisa, Pisa, Italy. r.ruffoli@med.unipi.it

Andrologia
|September 12, 2006
PubMed
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Chronic noise exposure increases lipofuscin in mouse testes, lowering testosterone. Diazepam pre-treatment prevents this lipofuscin accumulation and testosterone reduction, suggesting a protective role.

Area of Science:

  • Endocrinology
  • Toxicology
  • Cell Biology

Background:

  • Lipofuscin, an undegradable material, accumulates with age and stress, particularly oxidative stress.
  • Noise exposure is a significant stressor that can impact physiological functions.
  • Diazepam has shown potential in inhibiting lipofuscin formation and mitigating stress-induced effects.

Purpose of the Study:

  • To investigate if chronic noise exposure leads to lipofuscin accumulation in mouse testes.
  • To evaluate the impact of diazepam administration on noise-induced testicular changes.
  • To assess the effect of noise and diazepam on serum testosterone levels.

Main Methods:

  • Mice were exposed to white noise for 6 weeks, with or without diazepam pre-treatment.
  • Lipofuscin accumulation was assessed using light fluorescence and transmission electron microscopy.

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  • Serum testosterone levels were measured in all groups.

    • Main Results:

    • Chronic noise exposure resulted in significant lipofuscin accumulation in testicular Leydig cells.
    • Noise-exposed mice exhibited reduced serum testosterone levels.
    • Diazepam pre-treatment effectively prevented both lipofuscin accumulation and testosterone decrease.

    Conclusions:

    • Chronic noise exposure induces lipofuscin accumulation in Leydig cells and lowers testosterone levels.
    • Diazepam pre-treatment successfully mitigates these noise-induced testicular effects.
    • The protective effect of diazepam may involve peripheral benzodiazepine receptors in Leydig cells, enhancing resistance to oxidative stress.