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The Nucleosome

The Nucleosome

Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...

The Nucleosome

The Nucleosome

DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...

DNA Packaging

DNA Packaging

DNA Packaging

DNA Packaging

Single-Strand DNA Binding Proteins

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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Related Experiment Video

Updated: Jul 20, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

A DNA-centric look at protein-DNA complexes.

Taner Z Sen, Andrzej Kloczkowski, Robert L Jernigan

Structure (London, England : 1993)

|September 12, 2006

Summary

A new classification method groups DNA-protein structures into seven clusters based on binding interactions and DNA properties. This approach offers a novel way to understand these complex molecular structures.

Area of Science:

Structural Biology
Bioinformatics
Molecular Interactions

Background:

The increasing number of determined DNA-protein structures necessitates effective classification systems.
Previous classification schemes for DNA-protein complexes have limitations.

Discussion:

Prabakaran et al. introduce a novel classification system for DNA-protein structures.
This method integrates binding interaction data with intrinsic DNA properties.
The classification identifies seven distinct structural clusters.

Key Insights:

The proposed scheme significantly diverges from existing DNA-protein structure classifications.
It provides a new framework for analyzing the diversity of DNA-protein interactions.
This classification aids in understanding structure-function relationships.

More Related Videos

CD Spectroscopy to Study DNA-Protein Interactions

CD Spectroscopy to Study DNA-Protein Interactions

Published on: February 10, 2022

Related Experiment Videos

Last Updated: Jul 20, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

CD Spectroscopy to Study DNA-Protein Interactions

CD Spectroscopy to Study DNA-Protein Interactions

Published on: February 10, 2022

Outlook:

Further application of this classification may reveal new patterns in DNA recognition.
This approach could guide the design of novel DNA-binding proteins.
Future research can refine this classification with more structural data.