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Related Experiment Videos

Preparing chimpanzees for laboratory research.

Mollie A Bloomsmith1, Steven J Schapiro, Elizabeth A Strobert

  • 1Yerkes National Primate Research Center (YNPRC), Emory University, Atlanta, GA, USA. mabloom@emory.edu

ILAR Journal
|September 12, 2006
PubMed
Summary
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Careful management of chimpanzees in biomedical research is crucial due to their small population. This article discusses best practices for selecting, handling, and using these great apes in research to ensure ethical treatment and scientific quality.

Area of Science:

  • Primate research
  • Animal models in biomedical science
  • Great Ape research

Background:

  • Chimpanzees are the only Great Apes extensively used in biomedical research.
  • They serve as vital animal models for infectious diseases, neuroscience, cognition, and behavior studies.
  • Chimpanzee research in the U.S. is concentrated in specialized facilities.

Purpose of the Study:

  • To review best practices for selecting and handling chimpanzees in biomedical research.
  • To initiate a discussion on optimizing the care, production, and use of chimpanzees.
  • To address challenges related to the limited chimpanzee population in research.

Main Methods:

  • Review of selection criteria and preparation techniques for chimpanzee subjects.
  • Consideration of routine health assessments and behavioral factors for subject selection.

Related Experiment Videos

  • Discussion of experimental design and multiple-use strategies for chimpanzees.
  • Description of transportation and acclimation practices.
  • Exploration of behavioral conditioning techniques (habituation, desensitization, positive reinforcement).
  • Main Results:

    • Routine health assessments and behavioral considerations are key for subject selection.
    • Experimental design must account for the limited chimpanzee population, encouraging multiple uses.
    • Proper transportation and acclimation are essential for chimpanzee welfare.
    • Behavioral conditioning methods effectively reduce animal distress and enhance research quality.

    Conclusions:

    • Effective management of chimpanzee care, production, and use is imperative.
    • Implementing best practices in selection, handling, and experimental design improves research outcomes.
    • Behavioral conditioning is a valuable tool for minimizing distress and maximizing the scientific value of chimpanzee research.