Related Experiment Video
Updated: Jul 20, 2026

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
Published on: January 6, 2023
The MLL partial tandem duplication in acute myeloid leukaemia
Jorg Basecke1, Jarrett T Whelan, Frank Griesinger
1Division of Haematology and Oncology, University of Goettingen, Goettingen, Germany. jbaesec@gwdg.de
Abstract:
Mixed lineage leukaemia gene-partial tandem duplications (MLL-PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL-PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL-PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL-PTD.

