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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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Related Experiment Videos

Cutaneous vasculitis: diagnosis and management.

J Andrew Carlson1, L Frank Cavaliere, Jane M Grant-Kels

  • 1Division of Dermatology, Albany Medical College, MC-81, NY 12208, USA. carlsoa@mail.amc.edu

Clinics in Dermatology
|September 13, 2006
PubMed
Summary

Vasculitis involves blood vessel inflammation and destruction. Treatment ranges from general measures and NSAIDs for mild cases to potent immunosuppressants and biologics for severe or systemic disease.

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Area of Science:

  • Rheumatology
  • Dermatology
  • Immunology

Background:

  • Vasculitis is defined by inflammatory infiltration and destruction of blood vessels.
  • It can be primary (idiopathic) or secondary to other conditions.
  • Cutaneous vasculitis is a common manifestation of systemic vasculitic syndromes.

Purpose of the Study:

  • To review the classification and management of vasculitis, with a focus on cutaneous manifestations.
  • To outline treatment strategies based on disease severity and systemic involvement.

Main Methods:

  • Literature review of vasculitis classification, clinical presentation, and therapeutic approaches.
  • Discussion of pharmacologic interventions from general measures to advanced biologics.

Main Results:

  • Cutaneous vasculitis presents with diverse skin lesions and can be part of systemic diseases.
  • Mild cases often resolve with conservative measures and NSAIDs.
  • Recurrent or severe disease necessitates agents like colchicine, dapsone, or potent immunosuppressants.
  • Refractory cases may benefit from plasmapheresis or IV immunoglobulin.
  • Biologics like infliximab and rituximab show promise for specific vasculitic syndromes.

Conclusions:

  • Management of vasculitis requires tailored approaches based on disease type and severity.
  • A spectrum of treatments exists, from supportive care to advanced immunomodulatory therapies.
  • Emerging biologic therapies offer new options for refractory and specific vasculitic conditions.