Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 4, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.0K

A nanofluidic railroad switch for DNA.

Robert Riehn1, Robert H Austin, James C Sturm

  • 1Department of Physics, Princeton University, Princeton, New Jersey 08544, USA. rriehn@princeton.edu

Nano Letters
|September 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gradient metapopulation microfluidic ecologies shape genetic and biofilm drivers of T4r phage resistance in E. coli.

NPJ biofilms and microbiomes·2026
Same author

Informational Memory Shapes Collective Behavior in Intelligent Swarms.

Physical review letters·2026
Same author

Tunable single-column deterministic lateral displacement device by adjustable crossflow.

Lab on a chip·2026
Same author

Protocol to model tumor hypoxia in vitro using real-time phosphorescence-based sensing of O<sub>2</sub> gradients generated by metastatic cancer cells.

STAR protocols·2025
Same author

Plasmonic Double-Hole Bull's Eye Nanoantenna for Far-Field Polarization Control.

ACS nanoscience Au·2025
Same author

Probing protein-DNA interactions and compaction in nanochannels.

Current opinion in structural biology·2024

We developed a novel metamaterial with asymmetric nanochannels that directs DNA orientation and transport. Applying an AC voltage switches this direction, offering new control over nanoscale materials.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biophysics

Background:

  • Controlling the orientation and movement of DNA at the nanoscale is crucial for various applications.
  • Existing methods often lack precise directional control or require complex setups.

Purpose of the Study:

  • To design and characterize a metamaterial for directed DNA manipulation.
  • To investigate the influence of channel asymmetry and electric fields on DNA behavior.
  • To demonstrate switchable directional control of DNA orientation and transport.

Main Methods:

  • Fabrication of a two-dimensional, asymmetric lattice of crossed nanochannels in fused silica.
  • Introduction of DNA molecules into the nanochannels.
  • Application of DC and AC electrophoresis.

More Related Videos

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.1K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

6.7K

Related Experiment Videos

Last Updated: May 4, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.0K
Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.1K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

6.7K
  • Analysis of DNA orientation and transport using an energy landscape model.

    • Main Results:

    • Asymmetric nanochannels induce preferred DNA orientation and transport direction under DC electrophoresis.
    • Application of AC voltage allows for a 90-degree switch in the preferred orientation and transport axis.
    • The observed phenomena are explained by an energy landscape model incorporating entropic and dielectrophoretic forces.

    Conclusions:

    • The developed metamaterial provides tunable, switchable control over DNA orientation and transport.
    • This offers a new platform for manipulating polyelectrolytes at the nanoscale.
    • The findings have potential implications for DNA sequencing, sorting, and assembly.