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Related Experiment Video

Updated: Jan 7, 2026

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection
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Tunable single-column deterministic lateral displacement device by adjustable crossflow.

Miftahul Jannat Rasna1, James C Sturm1

  • 1Department of Electrical and Computer Engineering, Princeton University, Princeton, New Jersey, 08544, USA. mrasna@princeton.edu.

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PubMed
Summary
This summary is machine-generated.

This study introduces a tunable deterministic lateral displacement (DLD) device for size-based micro-particle separation. The novel single-column design offers adjustable critical size and high throughput, overcoming limitations of conventional DLD systems.

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Particle Separation Technology

Background:

  • Deterministic lateral displacement (DLD) devices enable high-resolution, size-based micro-particle separation using tilted micro-post arrays.
  • Conventional DLD devices lack tunability in critical particle size (Dc), which is fixed by geometry.
  • Traditional DLD devices require large footprints due to multiple rows/columns for particle separation, limiting throughput.

Purpose of the Study:

  • To develop a novel, tunable single-column deterministic lateral displacement (DLD) device.
  • To overcome the fixed critical size limitation of conventional DLD devices.
  • To enhance throughput and reduce device area for micro-particle separation.

Main Methods:

  • A single-column DLD device with 8 bumping obstacles was designed and fabricated.
  • Tunability of critical size (Dc) was achieved by adjusting perpendicular crossflow.
  • Device performance was evaluated for separation efficiency and throughput/area.

Main Results:

  • Demonstrated tunability of critical size (Dc) from below 5 μm to above 10 μm within a single device.
  • Achieved high separation efficiency of approximately 99.9%.
  • Obtained a high throughput/area of 45 μL min⁻¹ mm⁻².
  • Noted resolution degradation at high flow rates (Re > 10) due to 3D flow patterns.

Conclusions:

  • The novel tunable single-column DLD device offers a significant advancement over conventional designs.
  • This technology provides a compact and adaptable solution for precise micro-particle separation.
  • Further research may focus on optimizing performance at higher flow rates.