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Systemic diseases affecting osseointegration therapy.

Andrea Mombelli1, Norbert Cionca

  • 1School of Dental Medicine, University of Geneva, Geneva, Switzerland.

Clinical Oral Implants Research
|September 14, 2006
PubMed
Summary

Systemic diseases have limited evidence impacting osseointegration therapy success. While some studies suggest increased implant failure risk for diabetes, overall evidence for contraindications remains low due to sparse controlled research.

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Periodontology
  • Dental Implantology

Background:

  • Systemic diseases can influence oral health and implant outcomes.
  • Osseointegration therapy success is crucial for prosthetic rehabilitation.
  • Understanding disease impact guides treatment planning and patient selection.

Purpose of the Study:

  • To assess the effect of systemic diseases and their management on osseointegration therapy outcomes.
  • To identify potential contraindications for dental implant placement based on systemic health.
  • To review existing literature on systemic conditions and implant survival rates.

Main Methods:

  • Systematic literature search for human studies on osseointegrated oral implants.
  • Inclusion criteria: diagnosis of 11 systemic diseases, reporting implant survival.

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  • Exclusion of studies lacking controlled comparisons or sufficient data.

    • Main Results:

    • Limited controlled studies were found for most systemic conditions.
    • Evidence for implant therapy recommendations was generally low.
    • Diabetes: Heterogeneous data; no clear trend, but one study showed increased failure risk.
    • Osteoporosis: Heterogeneous data; low evidence for association with implant failure.

    Conclusions:

    • The evidence for absolute or relative contraindications for implant therapy due to systemic diseases is currently low.
    • Controlled studies comparing patients with and without specific systemic conditions are scarce.
    • Further high-quality research is needed to clarify the impact of systemic diseases on implant success.