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Updated: Jul 20, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
05:45

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

Adolescents and young adults with Hirschsprung's disease

Paul E Hyman1

  • 1Department of Pediatrics, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Mail stop 4004, Kansas City, KS 66160, USA. phyman@kumc.edu

Current Gastroenterology Reports
|September 14, 2006
PubMed

Insights

Most children with Hirschsprung

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Colorectal Surgery

Background:

  • Hirschsprung's disease often leads to long-term digestive and defecation issues post-surgery.
  • Adult diagnosis and management of Hirschsprung's disease are similar to pediatric cases.

Purpose of the Study:

  • To highlight the persistent challenges faced by patients after Hirschsprung's surgery.
  • To emphasize the role of colon manometry in managing persistent symptoms.
  • To explore factors influencing quality of life in Hirschsprung's disease patients.

Main Methods:

  • Review of long-term outcomes in patients undergoing Hirschsprung's disease resection.
  • Application of colon manometry for physiologic assessment of persistent symptoms.
  • Analysis of quality of life determinants.

Main Results:

  • A significant proportion of patients experience ongoing digestive and defecation problems.
  • Colon manometry provides valuable insights for guiding treatment in symptomatic individuals.
  • Quality of life is primarily linked to psychosocial aspects, not symptom severity.

Conclusions:

  • Long-term digestive and defecation issues are common after Hirschsprung's surgery.
  • Colon manometry is crucial for managing persistent symptoms.
  • Psychosocial factors significantly impact the quality of life for Hirschsprung's disease patients.

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