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Optimizing living donor kidney graft function by donor-recipient pair selection.

Todd V Brennan1, Alan Bostrom, Sandy Feng

  • 1Department of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA 94143-0780, USA.

Transplantation
|September 14, 2006
PubMed
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Choosing the best living kidney donor is crucial for transplant success. Donor and recipient factors like age and size significantly impact kidney graft function, helping select the optimal donor.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Biostatistics

Background:

  • Living donor kidney transplantation (LDKT) is increasingly common.
  • Selecting the optimal donor from multiple candidates can be challenging.
  • Donor and recipient factors influence post-transplant graft function.

Purpose of the Study:

  • To determine the impact of donor demographic factors on graft function after LDKT.
  • To develop a tool for selecting the best living kidney donor.

Main Methods:

  • Reviewed 8,603 adult LDKT cases from the Scientific Registry of Transplant Recipients (SRTR) (1999-2002).
  • Defined suboptimal one-year graft function as serum creatinine > 1.5 mg/dL.
  • Utilized logistic regression to identify factors associated with suboptimal graft function.

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Main Results:

  • Over one-third (36%) of LDKTs had suboptimal one-year graft function.
  • Recipient factors (age, gender, race, size) and donor factors (age, gender, size) were significant.
  • Recipient-donor relatedness also influenced graft function.

Conclusions:

  • Developed a predictive equation using donor and recipient characteristics.
  • This quantitative tool aids in selecting the optimal living kidney donor when multiple options exist.
  • Facilitates improved post-transplant outcomes in LDKT.