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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jun 11, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Complete Immunosuppression Withdrawal After Liver Transplantation: An International Multicenter Study.

Roberta Angelico1, Bruno Sensi2, Giuseppe Tisone1

  • 1Department of Surgical Sciences, University of Rome Tor Vergata, Rome, Italy.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|June 9, 2026
PubMed
Summary

Withdrawal of immunosuppression after liver transplantation (LT) can improve metabolic health and is feasible long-term. While mild graft changes may occur, they do not impact survival, suggesting potential for broader application.

Keywords:
Calcineurin InhibitorsLiver BiopsyTacrolimusToleranceWeaning

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Murine Full-thickness Skin Transplantation
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Last Updated: Jun 11, 2026

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Published on: November 8, 2015

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Published on: January 2, 2017

Area of Science:

  • Hepatology and Transplant Immunology
  • Graft Tolerance and Immunosuppression Management

Background:

  • Immunosuppression withdrawal (ISW) after liver transplantation (LT) is feasible in select patients, but long-term graft damage risks remain unclear.
  • Understanding clinical characteristics and outcomes of successful ISW is crucial for expanding its application.

Purpose of the Study:

  • To describe the clinical characteristics of patients undergoing successful ISW after LT.
  • To evaluate the long-term outcomes, including graft health and survival, following ISW.

Main Methods:

  • Retrospective cohort study across 31 LT centers in 15 countries.
  • Included adult and pediatric patients with ≥12 months of complete ISW.
  • Assessed long-term outcomes: histological graft injury, rejection, and mortality.

Main Results:

  • 287 patients (223 adults, 64 children) completed ISW, with a median 7.8-year follow-up.
  • ISW correlated with metabolic improvements (reduced diabetes and hypertension) and 43.5% achieved operational tolerance.
  • Despite some mild fibrosis (30.5%) or inflammation (22.2%), 5-year survival was 93% with no graft loss; these changes did not impact mortality.

Conclusions:

  • ISW post-LT can enhance metabolic comorbidities and is associated with good long-term outcomes.
  • Mild histological graft changes observed after ISW do not appear to compromise long-term graft survival.
  • Further research should explore expanding ISW to a wider LT patient population.