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Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
Published on: April 10, 2019
Duchenne's cardiomyopathy: two case reports.
Hangyuan Guo1, Jianyao Shen, Jong-Dae Lee
1Department of Cardiology, Shaoxing People's Hospital, First Affiliated Hospital of Medical College, Shaoxing University, Shaoxing, Zhejiang, China. ghangyuan@hotmail.com
Acta Cardiologica
|September 15, 2006
Summary
Two cases of Duchenne muscular dystrophy presented with severe heart dysfunction and muscle damage. These patients suggest a sporadic inheritance pattern for this severe cardiac condition.
Area of Science:
- Cardiology
- Neurology
- Genetics
Background:
- Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder.
- Cardiac involvement is a common and serious complication of DMD.
- Sporadic cases of DMD, particularly with severe cardiac manifestations, are less understood.
Observation:
- Two male patients presented with severe cardiac dysfunction and elevated serum creatine kinase.
- Clinical examination revealed mild skeletal myopathy and episodes of myoglobinuria upon exertion.
- Left ventriculography demonstrated diffuse severe hypokinesia, indicative of significant heart muscle impairment.
Findings:
- Skeletal muscle biopsy confirmed a dystrophic process consistent with DMD.
- Neither patient had a family history of DMD, suggesting a sporadic inheritance pattern.
- Both patients exhibited severe cardiac involvement despite minimal skeletal muscle symptoms.
Implications:
- These cases highlight the potential for sporadic DMD with severe cardiac phenotypes.
- Understanding sporadic inheritance patterns is crucial for accurate diagnosis and genetic counseling.
- Further research is needed to elucidate the genetic mechanisms underlying sporadic DMD and its cardiac complications.
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