[Drug allergy assessed by modified Shelley's test. A case series]

Area of Science:

• Clinical immunology
• Dermatology
• Pharmacology

Context:

• Drug allergy prevalence is 5-10% in the general population.
• Accurate diagnosis of drug allergy is crucial for patient safety.
• The Shelley's Modified Test is an in vitro diagnostic method for drug allergy.

Purpose:

• To evaluate the frequency of drug allergy using the Shelley's Modified Test.
• To correlate test results with clinical findings in patients diagnosed with drug allergy.

Summary:

• A study of 165 patients diagnosed with drug allergy found 88% positive results with the Shelley's Modified Test.
• Antibiotics were the most common cause of drug allergy, with urticaria being the most frequent clinical manifestation.
• The Shelley's Modified Test is a valuable tool for supporting drug allergy diagnosis, particularly in cases involving antibiotics.

Impact:

• Highlights the utility of the Shelley's Modified Test in clinical practice.
• Identifies key drug classes and clinical presentations associated with drug allergy.
• Informs diagnostic strategies and patient management for suspected drug allergies.