Related Experiment Videos
[Minocycline-induced lupus erythematodes]
S S Egger1, I Gehrig Studer, A E Rätz Bravo
1Klinische Pharmakologie & Toxikologie, regionales Pharmacovigilance-Zentrum, Universitätsspital, Basel. eggers@uhbs.ch
Praxis
|September 15, 2006
Summary
Minocycline can trigger drug-induced lupus, characterized by joint pain and rashes, especially in young adults. Promptly discontinuing minocycline can resolve these lupus-like symptoms.
Area of Science:
- Rheumatology
- Dermatology
- Pharmacology
Background:
- Minocycline, a tetracycline antibiotic, is commonly prescribed for acne vulgaris.
- Drug-induced lupus erythematosus (DILE) is a recognized adverse effect of various medications.
Observation:
- An 18-year-old female presented with arthralgia, hand/foot joint swelling, photosensitivity, butterfly rash, fatigue, tachypnea, and cardiac pain after three months of minocycline therapy for acne.
- Symptom exacerbation occurred rapidly upon minocycline re-challenge.
- Antinuclear antibody (ANA) testing was positive.
Findings:
- Minocycline-induced lupus was diagnosed after symptom improvement upon drug withdrawal.
- A review of adverse drug reaction databases identified 267 additional suspected cases of minocycline-induced lupus.
- Common features include arthralgia, arthritis, myalgia, elevated transaminases, jaundice, fatigue, fever, skin manifestations, and positive ANA.
Implications:
- Minocycline should be considered a potential cause of drug-induced lupus.
- Awareness of DILE associated with minocycline is crucial for early diagnosis and management.
- Discontinuation of minocycline is the primary treatment for minocycline-induced lupus.
