Population-based prevalence of repeated group A beta-hemolytic streptococcal pharyngitis episodes

Jennifer L St Sauver1, Amy L Weaver, Laura J Orvidas

  • 1Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. stsauver.jennifer@mayo.edu

Mayo Clinic Proceedings
|September 15, 2006
PubMed

Insights

Approximately 1% of children aged 4-15 experienced recurrent group A beta-hemolytic streptococcal (GABHS) pharyngitis over three years. This highlights a significant public health concern despite the low prevalence of recurrent GABHS infections.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Recurrent group A beta-hemolytic streptococcal (GABHS) pharyngitis poses a challenge in pediatric care.
  • Understanding the population-based prevalence of repeated GABHS episodes is crucial for public health management.

Purpose of the Study:

  • To determine the 3-year period prevalence of recurrent GABHS pharyngitis in children aged 4 to 15 years.
  • To analyze age-specific prevalence rates of repeated GABHS infections.

Main Methods:

  • A population-based study was conducted in Rochester, Minn., from 1996 to 1998.
  • Identified children (4-15 years) with 3+ GABHS pharyngitis episodes/year, at least 1 month apart, using the Rochester Epidemiology Project.
  • Defined GABHS episodes by sore throat with positive rapid strep test or culture.

Main Results:

  • 208 children met the criteria for repeated GABHS episodes between 1996 and 1998.
  • Approximately 1% of children aged 4-15 experienced recurrent GABHS pharyngitis during the study period.
  • Prevalence was higher in younger children (2% in 4-6 years) and lower in older children (0.1% in 13-15 years).

Conclusions:

  • A small proportion of children experience recurrent GABHS pharyngitis, but this affects a substantial number at the population level.
  • Recurrent GABHS infections are associated with increased healthcare costs.
  • Further research is needed to identify strategies for reducing recurrent GABHS episodes and associated costs in children.
Abstract

Related Concept Videos

Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...