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Published on: June 11, 2012
Simultaneous control of intermediate diabetes outcomes among Veterans Affairs primary care patients
George L Jackson1, David Edelman, Morris Weinberger
1Durham Veterans Affairs Medical Center, Durham, NC, USA. george.l.jackson@duke.edu
Insights
Simultaneous control of hemoglobin A1c (HbA1c), LDL cholesterol (LDL-C), and blood pressure (BP) is low in diabetes patients. While individual targets are often met, achieving all three concurrently remains a challenge.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Public Health
Background:
- Current guidelines recommend strict control of hemoglobin A1c (HbA1c), low-density lipoprotein cholesterol (LDL-C), and blood pressure (BP) for diabetes management.
- However, the extent to which these critical intermediate outcomes are simultaneously controlled in patient populations is not well-documented.
Purpose of the Study:
- To assess the degree of simultaneous control of HbA1c, LDL-C, and BP in Veterans Affairs (VA) diabetes patients.
- This evaluation was performed using both the 1997 VA guidelines and the 2004 American Diabetes Association (ADA) guidelines.
Main Methods:
- A cross-sectional cohort study was conducted.
- The study included 80,207 VA diabetes patients treated between October 1999 and September 2000.
- Simultaneous control was defined by achieving target levels for HbA1c, LDL-C, and BP according to both VA and ADA criteria.
Main Results:
- Using VA guidelines (HbA1c < 9.0%, LDL-C < 130 mg/dL, BP < 140/90 mmHg), 31% of patients achieved simultaneous control.
- Under stricter ADA guidelines (HbA1c < 7.0%, LDL-C < 100 mg/dL, BP < 130/80 mmHg), only 4% of patients had simultaneous control.
- Individual outcome control rates were higher (HbA1c 82%, LDL-C 77%, BP 48% for VA; HbA1c 36%, LDL-C 41%, BP 23% for ADA), but associations between achieving control for individual factors were weak.
Conclusions:
- Despite high rates of achieving individual targets for HbA1c and LDL-C, simultaneous control of HbA1c, LDL-C, and BP is notably low in this VA diabetes patient cohort.
- Factors such as higher body mass index, African American or Hispanic race-ethnicity, and female gender were associated with lower odds of simultaneous control.
Background:
Guidelines recommend tight control of hemoglobin A1c (HbA1c), low-density lipoprotein cholesterol (LDL-C), and blood pressure (BP) for patients with diabetes. The degree to which these intermediate outcomes are simultaneously controlled has not been extensively described.
Objective:
Describe the degree of simultaneous control of HbA1c, LDL-C, and BP among Veterans Affairs (VA) diabetes patients defined by both VA and American Diabetes Association (ADA) guidelines.
Design:
Cross-sectional cohort.
Patients:
Eighty-thousand two hundred and seven VA diabetes patients receiving care between October 1999 and September 2000.
Measurments:
We defined simultaneous control of outcomes using 1997 VA Guidelines (in place in 2000) (HbA1c < 9.0%; LDL-C < 130 mg/dL; systolic BP < 140 mmHg; and diastolic BP < 90 mmHg) and 2004 ADA guidelines (HbA1c < 7.0%; LDL-C < 100 mg/dL; systolic BP < 130 mmHg; and diastolic BP < 80 mmHg). A patient is considered to have simultaneous control of the intermediate outcomes for a given definition if the average of measurements for each outcome was below the defined threshold during the study period.
Results:
Using VA guidelines, 31% of patients had simultaneous control. Control levels of individual outcomes were: HbA1c (82%), LDL-C (77%), and BP (48%). Using ADA guidelines, 4% had simultaneous control. Control levels of individual outcomes were: HbA1c (36%), LDL-C (41%), and BP (23%). Associations between individual risk factors were weak. There was a modest association between LDL-C control and control of HbA1c (odds ratio [OR] 1.51; 95% confidence interval [CI] 1.44, 1.58). The association between LDL-C and BP control was clinically small (1.26; 1.21, 1.31), and there was an extremely small association between BP and HbA1c control (0.95; 0.92, 0.99). Logistic regression modeling indicates greater body mass index, African American or Hispanic race-ethnicity, and female gender were negatively associated with simultaneous control.
Conclusion:
While the proportion of patients who achieved minimal levels of control of HbA1c and LDL-C was high, these data indicate a low level of simultaneous control of HbA1c, LDL-C, and BP among patients with diabetes.
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