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Administration of intravenous tissue plasminogen activator in a pediatric patient with acute ischemic stroke

Marwan I Shuayto1, J Ivan Lopez, Frank Greiner

  • 1Department of Neurology, University of South Alabama, College of Medicine, Mobile 36693, USA. M_Shuayto_MD@yahoo.com

Journal of Child Neurology
|September 15, 2006
PubMed

Insights

Intravenous tissue plasminogen activator (tPA) is an FDA-approved treatment for acute ischemic strokes. This case report shows tPA can be safe and effective for pediatric patients, with rapid symptom resolution and full recovery.

Area of Science:

  • Neurology
  • Pediatric Medicine
  • Emergency Medicine

Background:

  • The US Food and Drug Administration (FDA) has approved intravenous tissue plasminogen activator (tPA) as the sole therapy for acute ischemic strokes.
  • The pivotal National Institutes of Health (NIH)-sponsored trial that supported tPA approval excluded patients under 18 years of age.

Observation:

  • This report details a case involving a pediatric patient who experienced a dominant-hemisphere acute ischemic stroke.
  • The patient received intravenous tPA for treatment.

Findings:

  • Symptomatic improvement was observed within 4 hours post-treatment.
  • Complete clinical recovery was achieved after 8 hours.
  • The administration of tPA was well-tolerated, with no reported complications.

Implications:

  • Intravenous tPA may be a safe and effective treatment option for acute ischemic strokes in pediatric populations.
  • Further investigation through randomized, controlled, double-blind studies is warranted to confirm these findings in younger patients.

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