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Updated: Jul 20, 2026

Operant Procedures for Assessing Behavioral Flexibility in Rats
Published on: February 15, 2015
Plan to be flexible: a commentary on adaptive designs
1Department of Biostatistics, School of Public Health, University of Medicine and Dentistry of New Jersey, USA. shihwj@umdnj.edu
Abstract:
This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'Nested repeated confidence intervals and switching between noninferiority and superiority' by Joachim Hartung and Guido Knapp; 'Confirmatory Seamless Phase II/III Clinical trials with Hypotheses Selection at Interim: General Concepts' by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer; and 'Confirmatory Seamless Phase Il/III Clinical Trials with Hypotheses Selection at Interim: Applications and Practical Considerations' by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer.
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