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Related Experiment Videos

High-throughput screening: update on practices and success.

Sandra Fox1, Shauna Farr-Jones, Lynne Sopchak

  • 1HighTech Business Decisions, Moraga, California 94556, USA. sfox@hightechdecisions.com

Journal of Biomolecular Screening
|September 16, 2006
PubMed
Summary
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High-throughput screening (HTS) is integral to drug discovery, expanding into new applications like target validation and lead optimization. HTS laboratories continuously seek new technologies to improve drug candidate success rates.

Area of Science:

  • Drug discovery and development
  • Biotechnology
  • Pharmaceutical industry

Background:

  • High-throughput screening (HTS) is a critical component of modern drug discovery.
  • Its application is expanding across various stages, including target validation, assay development, and lead optimization.
  • The integration of HTS is increasing both upstream and downstream in the drug discovery pipeline.

Purpose of the Study:

  • To provide an overview of the current state and expanding applications of HTS in drug discovery.
  • To highlight the ongoing evaluation of new technologies by HTS laboratories to enhance success rates.
  • To present insights based on a comprehensive industry report involving HTS directors and suppliers.

Main Methods:

  • The content is derived from a detailed industry report.

Related Experiment Videos

  • The report involved 54 HTS directors from 58 HTS laboratories.
  • Data was also collected from 34 suppliers in the HTS field.

    • Main Results:

    • HTS is increasingly utilized in diverse areas such as target validation, assay development, secondary screening, ADME/Tox, and lead optimization.
    • There is a growing adoption of cell-based assays and high-content screening (HCS) for more relevant and higher-quality lead identification.
    • HTS laboratories are actively exploring novel technologies to improve the success rate of identifying drug candidates.

    Conclusions:

    • HTS is a fully integrated technology in drug discovery, essential for identifying viable drug candidates.
    • The continuous evolution and adoption of new HTS technologies, including HCS, are crucial for improving drug discovery efficiency and success.
    • Industry-wide collaboration and data from HTS directors and suppliers offer valuable insights into the field's trajectory.