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Updated: Aug 10, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Collagenous structures present in brain contain epitopes shared by collagen and microtubule-associated protein tau
E Montejo de Garcini1, J L Carrascosa, A Nieto
1Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma, Madrid, Spain.
Abstract:
A novel type of collagenous fibers has been isolated from human brain and characterized by electron microscopy and optical diffraction. It was found that the morphology of the fibers is similar, but not identical, to that of skin collagen. Also, the collagenous fibers show some similarities with the paracrystals that could be assembled in vitro from purified microtubule-associated protein tau. Immunological analyses indicated the presence of epitopes in these collagenous fibers which react with antibodies against collagen and tau.
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