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Poliomyelitis

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...

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Related Experiment Video

Updated: Jul 20, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Acute transverse myelitis in children.

Syed Asif Masood¹, Shahnaz Ibrahim

¹Department of Pediatrics, Louisiana State University, Shreveport, USA. asifmasood2@rediffmail.com

Journal of Ayub Medical College, Abbottabad : JAMC

|September 19, 2006

Summary

Acute Transverse Myelitis (ATM) is a rare childhood disease. Diagnosis involves clinical, CSF, and imaging data, with treatment including IV methylprednisolone, though recovery varies.

Area of Science:

Neurology
Pediatrics
Immunology

Background:

Acute Transverse Myelitis (ATM) is a rare neurological disorder affecting the spinal cord.
Pediatric cases of ATM present diagnostic challenges due to overlapping symptoms with other conditions.

Observation:

This case report details the diagnostic process for pediatric ATM.
Diagnostic methods included clinical evaluation, cerebrospinal fluid analysis, and spinal cord imaging.
Differential diagnoses such as Guillain-Barre syndrome (GBS) and Poliomyelitis were systematically excluded.

Findings:

The diagnosis of ATM was confirmed through a comprehensive evaluation.
Intravenous (IV) methylprednisolone was proposed as the treatment strategy.
Prognosis for recovery in pediatric ATM remains variable.

Related Experiment Videos

Last Updated: Jul 20, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Implications:

Highlights the importance of a thorough diagnostic approach for pediatric ATM.
Suggests the need for further research into the epidemiology, etiology, and prognosis of ATM.
Emphasizes the potential role of corticosteroids in managing pediatric ATM.