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Characterization of hydroxypropylmethylcellulose films using microwave non-destructive testing technique
Nor Khaizan Anuar1, Wong Tin Wui, Deepak K Ghodgaonkar
1Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.
Journal of Pharmaceutical and Biomedical Analysis
|September 19, 2006
Summary
Microwave non-destructive testing (NDT) effectively characterizes pharmaceutical film matrix properties by detecting polymer-drug interactions. This technique shows promise for monitoring film matrix states, crucial for drug formulation stability.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Analytical Chemistry
Background:
- Pharmaceutical films require precise characterization of matrix properties for drug efficacy and stability.
- Understanding polymer-polymer and drug-polymer interactions is vital for predicting film behavior.
- Non-destructive testing methods offer advantages for in-process and final product quality control.
Purpose of the Study:
- To investigate the applicability of microwave non-destructive testing (NDT) for characterizing the matrix properties of pharmaceutical films.
- To correlate microwave NDT measurements with physicochemical changes in hydroxypropylmethylcellulose (HPMC) films under varying humidity conditions.
- To assess the sensitivity of microwave NDT to polymer-polymer and drug-polymer interactions.
Main Methods:
- Preparation of blank and drug-loaded HPMC films (loratadine) using solvent-evaporation.
- Conditioning of films at relative humidities of 25%, 50%, and 75%.
- Physicochemical characterization using microwave NDT, UV spectrophotometry, DSC, and FT-IR.
Main Results:
- Microwave NDT results correlated with polymer-polymer and drug-polymer interactions, influenced by relative humidity.
- Microwave absorption and transmission varied with the state of interaction at O-H and C-H moieties.
- Sensitivity of microwave NDT to O-H and C-H moieties was frequency-dependent (8GHz vs. higher bands).
Conclusions:
- Microwave NDT is a sensitive technique for detecting polymer-polymer and drug-polymer interactions in pharmaceutical films.
- The technique can serve as an indicator of the matrix state, influenced by environmental conditions like humidity.
- Microwave NDT holds potential for quality control in pharmaceutical film manufacturing.
