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Engineering tissues for in vitro applications.

Salman R Khetani1, Sangeeta N Bhatia

  • 1Harvard MIT Division of Health Sciences and Technology/Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E19-502D, Cambridge, MA 02139, USA.

Current Opinion in Biotechnology
|September 19, 2006
PubMed
Summary
This summary is machine-generated.

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Engineered tissues advance biological research and drug development. Recent technological advancements enable sophisticated in vitro tissue construction and study for deeper insights.

Area of Science:

  • Biotechnology and Tissue Engineering
  • Developmental Biology
  • Pharmacology

Background:

  • Engineered tissues are valuable tools for studying embryology, physiology, and disease.
  • They offer platforms for evaluating new drug candidates.
  • Progress in tissue engineering is crucial for advancing biological research.

Purpose of the Study:

  • To highlight recent technological advancements in engineered tissue development.
  • To emphasize the potential of these technologies for in vitro research.
  • To showcase the sophisticated capabilities for constructing and studying engineered tissues.

Main Methods:

  • Utilizing microfabrication tools for precise cellular microenvironment control and assay parallelization.
  • Employing synthetic, tunable hydrogels for creating three-dimensional cellular environments.

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  • Leveraging bioreactors to manage nutrient transport and fluid shear stress.

    • Main Results:

    • Microfabrication enables defined cellular microenvironments and parallelized assays.
    • Tunable hydrogels facilitate the creation of 3D tissue models.
    • Bioreactors allow for controlled physiological conditions in vitro.
    • The convergence of these technologies allows for unprecedented sophistication in engineered tissues.

    Conclusions:

    • Recent technological advancements have significantly improved in vitro engineered tissue capabilities.
    • These tools provide powerful platforms for fundamental biological research and drug discovery.
    • The sophisticated construction and study of engineered tissues offer new avenues for scientific investigation.